Profhilo Structura
Profhilo Structura is an injectable hyaluronic acid preparation intended for facial treatment, with a focus on the superficial facial fat tissue and the changes in support that accompany ageing. It is considered in appropriately selected patients with volume loss and contour changes, following an examination and facial anatomy assessment.
Profhilo Structura – in brief
| What it is | Product with 90 mg of hyaluronic acid in 2 ml |
|---|---|
| What it treats | Superficial facial fat compartments and loss of support in selected patients |
| Anaesthesia | Anaesthetic cream |
| Duration of treatment | About 20 minutes |
| Number of treatments | Two treatments four weeks apart |
| Recovery | Possible swelling, redness, tenderness and bruising; duration is individual |
| Duration of results | Individual; assessed at follow-up visits after the initial course |
What is Profhilo Structura?
Profhilo Structura contains 90 mg of hyaluronic acid in 2 ml. It was developed by IBSA for facial treatment and fatty tissue restoration. Its purpose differs from that of a conventional skin booster, which is primarily focused on skin hydration.
Profhilo and Structura – what is the difference?
Profhilo is used for skin hydration and elasticity, whereas Profhilo Structura is also intended for changes in the superficial facial fat tissue. They differ in their purpose and injection technique.
| Profhilo | Profhilo Structura | |
|---|---|---|
| Composition | 64 mg of hyaluronic acid in 2 ml | 90 mg of hyaluronic acid in 2 ml |
| What it treats | Skin hydration, tone and elasticity | Superficial facial fat tissue and loss of support |
| Areas | Face and neck | Face |
| Initial plan | Two sessions about a month apart | Two treatments four weeks apart |
Results are evaluated gradually
In a pilot study with 50 female participants, two sessions were performed one month apart, and a follow-up visit took place three months after the end of treatment. This shows why the outcome is evaluated over time. The study is observational and does not represent a guarantee of results for every patient.
Manufacturer's documentation: IBSA – product leaflet. The protocol is aligned with the instructions for use that accompany the product.
Profhilo Structura treatment
Why is hyaluronic acid important?
Hyaluronic acid is a natural tissue component that binds water. The effect of the injectable preparation also depends on its formulation, the treatment area and the injection depth. Therefore, ordinary skin hydration should not be equated with the treatment of superficial facial fat tissue.
How does Profhilo Structura work?
Structura is used with the aim of improving facial tissue support and appearance in selected superficial fat compartments. It contains high and low molecular weight hyaluronic acid complexes obtained by NAHYCO technology.
Clinical studies describe changes to tissue and facial appearance, but do not justify the promise of generating new fat cells or an equal lifting effect in all patients. The plan is tailored to the anatomy and the degree of changes.
Who is Profhilo Structura for?
Treatment is considered in adults in whom examination shows loss of support and changes in superficial facial fat tissue. Dry skin alone is not a sufficient reason for choosing Structura.
It is not a universal preventive treatment for young people, nor is it a replacement for surgical correction of pronounced excess skin. The doctor assesses whether Structura, Profhilo for skin quality or another procedure is more appropriate.
Profhilo Structura treatment price
You can find the price of the Profhilo Structura treatment in our Price list.
Have a question?
Answers to frequently asked questions
What does a Profhilo Structura treatment look like?
Following an examination and a discussion about expectations, the doctor determines the treatment area, the injection technique and the amount of the product. Structura is applied into the appropriate tissue layer, according to the product instructions and the individual plan. Discomfort, swelling and bruising are possible.
Unlike the preparations primarily intended for hydration, described in our article about skin booster, here the focus is on the support of the superficial facial fat tissue.
What are the effects of the Profhilo Structura treatment?
The aim is to improve tissue support and facial contour in suitably indicated patients. The change can be subtle and gradual. It is not possible to promise the same degree of improvement in all patients beforehand.
Does Profhilo Structura change the volume and contour of the face?
Structura is not used in the same way as a classic filler for precisely shaping a single area. However, it can affect facial fullness and contour, so the claim that it “does not provide volume at all” is not sufficiently precise. The goal and limits of the treatment are explained by a doctor after an examination.

How many Profhilo Structura treatments are needed?
The initial course typically involves two sessions about a month apart. Additional treatments and maintenance depend on the doctor's assessment, tissue response and the instructions for the specific product.
When will I see results and how long do they last?
Results are assessed over the weeks and months following the initial course. Immediate swelling is not the final effect. Published research has a limited follow-up duration, so the same timeframe for results to appear or last cannot be promised to everyone.
Is the treatment painful?
Before the procedure, an anaesthetic cream is applied to make the treatment as comfortable as possible. During the application, a mild stinging sensation or pressure may be felt, but patients generally tolerate this well.
Is there a recovery period?
Following application, redness, swelling, tenderness and bruising may occur. Their duration varies among patients, so resolution within a few hours is not guaranteed. The doctor will provide instructions for aftercare and the resumption of activities. If severe or increasing pain, unusual skin discolouration or visual disturbances occur, seek medical attention immediately.
What is the difference between Profhilo and Profhilo Structura?
Profhilo is aimed primarily at skin hydration, elasticity, and quality. Structura is also intended for the treatment of superficial facial fat tissue when there is an appropriate indication. The preparations are not interchangeable; the choice and possible combination are determined by a physician.
Can I have Structura if I already have filler or a collagen stimulator?
Yes, Structura can be part of a plan that includes fillers or collagen stimulators. At the consultation, we agree on the order and interval between treatments for the area you wish to treat.
Contraindications
The treatment is not without risk. It is not used during pregnancy and breastfeeding, in cases of active inflammation in the treated area, hypersensitivity to the ingredients, or other contraindications from the product instructions. Diseases, therapies, and previous aesthetic procedures should be reported to the doctor. The final decision is made after an examination.
Book a Profhilo Structura treatment in Belgrade
Imedic poliklinika is located at Kneza Miloša 23, 2nd floor, Belgrade. Opening hours: Monday–Sunday, 9:00–21:00.
Appointments can be booked by phone: 064 237 0707. If you contact us from abroad, we are also available via Viber and WhatsApp on the same number.
Treatment planning
We recommend planning your injectable treatment at least two weeks before an important event. If a series of treatments is required, the plan should start earlier to allow enough time for the full effect to develop.
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Author: Dr Ivica Jeremić
PhD in Medical Sciences (Molecular Medicine and Immunology), rheumatology subspecialist, dermatology resident.
