Collagen stimulators

HArmonyCa is a hybrid collagen stimulator that combines hyaluronic acid and calcium hydroxylapatite. It is precisely this combination that sets it apart from other treatments – it acts simultaneously on tissue structure and skin quality.

After injection, the hyaluronic component provides immediate support in areas where support has weakened, most commonly in the cheek area and along the jawline. At the same time, calcium hydroxylapatite microspheres trigger the process of new collagen creation, which develops over the following weeks.

What makes HArmonyCa unique is precisely this dual effect – the initial stabilisation of contours and the gradual improvement in skin firmness. As collagen forms over time, the skin gains better structure and resilience, and its appearance becomes more even and defined.

Because of this mode of action, HArmonyCa is the treatment of choice when it is necessary to improve both tissue support and skin quality at the same time, without sudden changes in appearance.

Karisma is a collagen stimulator that works through a carefully balanced combination of three ingredients – collagen, hyaluronic acid, and carboxymethylcellulose. This combination enables the simultaneous improvement of hydration, structure, and regenerative processes in the skin.

Its uniqueness lies in the use of collagen whose structure is very close to human type I collagen. After being injected into the middle or deeper layer of the dermis, this ingredient acts as a signal to fibroblasts to start more intensive production of their own collagen. At the same time, hyaluronic acid contributes to better hydration, while carboxymethylcellulose slows down its degradation and prolongs the effect in the skin.

Unlike volumising treatments, Karisma focuses on skin quality. It is used in areas where changes are subtle yet visible – on the face, neck and décolletage, as well as for skin that has lost its tone or shows fine lines, scars or textural irregularities.

After the treatment, the skin becomes more hydrated, elastic and even. The effect develops over time, without sudden changes, which contributes to a natural appearance. It is particularly suitable for people who want a discreet improvement and the preservation of skin quality, without pronounced volume.

The treatment is usually carried out in a series of two visits a few weeks apart, while the effects are maintained for months with the possibility of occasional maintenance.

AesPlla is a collagen stimulator based on poly-L-lactic acid (PLLA), designed for a more pronounced improvement in skin structure and the gradual restoration of volume. Unlike treatments that provide an immediate effect, AesPlla works by stimulating the body to build its own new network of collagen.

After injection into the deeper layers of the skin, PLLA particles trigger a process that takes place over time. Over the coming weeks and months, new collagen is produced, which affects the firmness, density and support of the tissue. Precisely for this reason, the changes do not happen suddenly, but develop gradually and become increasingly pronounced as the process progresses.

This treatment is used when there are more pronounced changes in facial structure, such as volume loss in the cheeks or temples, or sagging in the lower third of the face. In addition to the face, it can also be applied to the body, in areas where there has been a loss of skin tone and firmness.

Another distinctive feature of AesPlla is the aftercare – it is essential that the product is evenly distributed throughout the tissue, which is why massage is advised in the days following the treatment. This step is important for the proper development of the effect.

Results start to become visible after a few weeks, while the full effect develops over several months. The result is stable and long-lasting, as it is based on newly formed collagen and a change in the skin structure itself.

AesPlla is the choice when the goal is a deeper improvement in skin support and quality, with a gradual and long-lasting result.

Lanluma is a collagen stimulator based on poly-L-lactic acid (PLLA), designed for a more pronounced improvement in skin firmness and the gradual restoration of volume. What sets it apart is that it comes in two formulations, so it can be used on both the face and larger areas of the body.

After injection into the deeper layers of the skin or subcutaneous tissue, PLLA particles act as a scaffold around which a new network of collagen is formed over time. This process takes place gradually, so the changes also develop over time – the skin becomes firmer, more resilient and better defined.

Lanluma V is designed for the face, neck and décolletage, where it is used to improve skin structure, as well as in regions such as the cheeks and temples, where volume has been lost. The effect is discreet and gradual, with a focus on tissue quality and stability.

Lanluma X is a higher-concentration formulation designed for body treatments. It is used in areas where it is necessary to improve volume and tone, such as the buttocks, thighs or upper arms. In these areas, it enables gradual shaping and skin tightening through the body's own collagen production.

Unlike treatments that provide an immediate effect, Lanluma relies on an ongoing process – the results develop over several months and are maintained long-term, as they are based on newly formed collagen.

Because of this feature, Lanluma is the choice when the goal is a more pronounced improvement in structure and volume, both on the face and on the body, with a gradual and natural development of results.

Ellansé is a collagen stimulator that stands out for the way it combines an immediate effect with long-term improvement in skin structure. Its composition allows the result to be seen immediately after injection, whilst further improvement develops over the subsequent period thanks to the generation of new collagen.

Following injection, the gel carrier provides initial support to the tissue and helps fill areas where volume has been lost. At the same time, polycaprolactone (PCL) microspheres act as a stimulant for fibroblasts, thereby initiating the process of collagen production which, over time, takes over the role of the initial volume.

This transition from the material to one's own tissue is what makes Ellansé unique – the result is not suddenly lost, but is gradually maintained through a change in the skin structure.

Ellansé is most commonly used in areas where more precise definition and stable support are needed, such as the cheeks, nasolabial folds, jawline and chin, as well as the temple area. It is also suitable for the treatment of the hands, where it contributes to a more even skin appearance.

Unlike poly-L-lactic acid-based stimulators, intensive massage is not required after this treatment, and the volume remains stable from the very beginning. This allows for greater control over the result and clearer contouring.

The duration of the effect depends on the chosen formulation and can be tailored to individual needs, as there are variants that differ in the length of their action.

Radiesse

Radiesse is a collagen stimulator based on calcium hydroxylapatite (CaHA), a substance naturally present in the body. Its special feature is that it simultaneously provides tissue support and stimulates the production of new collagen, thereby affecting both the structure and quality of the skin.

Following injection, the gel carrier provides initial stability in the treated area, while the calcium microspheres act on fibroblasts and trigger the production of collagen and elastin. As the carrier gradually degrades, the newly formed tissue takes over its role, thereby maintaining the achieved result.

What sets Radiesse apart is its flexibility in application. Depending on the method of preparation, it can be used to define facial contours more clearly, such as the jawline and chin, but also for improving skin quality when applied in a diluted form. In that case, it does not affect volume, but rather the firmness, elasticity and texture of the skin.

It is most commonly used in the lower third of the face, as well as on the hands, where it contributes to a more even skin appearance. It is also suitable for treatments of the neck and décolletage when the goal is to improve skin tone and quality.

Unlike poly-L-lactic acid-based stimulators, intensive massage is not required after treatment, and the structure of the preparation allows for even distribution within the tissue. The results develop through a combination of initial support and subsequent biostimulation and typically last for several months.

Radiesse is the choice when a stable and precisely controlled effect is needed, along with the simultaneous improvement of skin quality.

We recommend planning your injectable treatment at least two weeks before an important event. If a series of treatments is required, the plan should start earlier to allow enough time for the full effect to develop.

Collagen stimulators also include Lenisna (Juvelook Volume). More detailed information about this preparation, its application and the course of treatment can be found on a separate page. The doctor chooses the product after a consultation.