PRP facial treatment

PRP facial treatment is a regenerative therapy that uses platelet-rich plasma obtained from the patient's own blood. Thanks to the high concentration of growth factors, PRP stimulates the skin's natural regeneration processes and helps improve the tone, texture and quality of the tissue, without introducing foreign substances.

PRP facial treatment – in brief

What is being treatedQuality, tone and texture of the skin of the face, neck and décolletage
MethodPlasma obtained from one's own blood
AnaesthesiaLocal anaesthetic cream, as required
Duration of treatment30 to 40 minutes
Number of treatmentsUsually a series of three treatments spaced about a month apart, with maintenance once to twice a year
ResultGradually, over the coming weeks
RecoveryReturn to activities immediately; possible redness and minor bruising with sensitive skin

What is a PRP facial treatment?

PRP treatment is a regenerative medical procedure that uses platelet-rich plasma obtained from the patient's own blood. This plasma contains a high concentration of growth factors – biologically active molecules that play a key role in the processes of repair and tissue healing. Following centrifugal separation, the concentrated plasma is micro-injected into the skin of the face, neck or décolletage. When the platelets are activated within the tissue, they release growth factors that stimulate collagen synthesis, improve microcirculation and encourage cellular regeneration. The effect of the PRP treatment is not based on adding volume or introducing foreign materials, but on activating the body's natural biological mechanisms. The result is a gradual improvement in skin quality – better tone, a more even texture and a healthier appearance, in accordance with the skin's individual regenerative potential.

PRP therapy

PRP facial treatment is intended for people who are noticing the first signs of loss of skin tone, elasticity and freshness, as well as those who want to stimulate natural regeneration without adding volume or foreign substances. It is particularly recommended for tired, dehydrated and thin skin, as well as for fine lines and early signs of ageing.

The treatment can be a good choice for patients who want a gradual and biologically based improvement in the quality of the skin of the face, neck and décolletage. It is also used for individuals with atrophic acne scars, most commonly in combination with other regenerative procedures, in accordance with the doctor's assessment.

The decision to carry out PRP treatment is made individually, following an examination and an assessment of the general state of health, so that the therapeutic goal is realistic and medically justified.

Before carrying out the PRP treatment, the doctor performs a detailed assessment of the skin condition and determines the number of treatments, as well as the intervals between them, in accordance with the therapeutic goal and the regenerative potential of the skin.

Following the examination, a small amount of blood is taken, similar to a standard laboratory analysis. The blood is collected in special tubes intended for the isolation of platelet-rich plasma, and is then processed in a centrifuge to isolate the concentrated fraction with a high concentration of growth factors.

Before application, the skin is prepared and, if necessary, a topical anaesthetic cream is applied for greater patient comfort. The resulting plasma is then introduced into the skin using fine needles, via a technique similar to mesotherapy.

Upon application, platelets release growth factors that activate cellular regeneration mechanisms, stimulate the synthesis of collagen and elastin, and initiate tissue repair processes. The procedure can similarly be applied to the skin of the neck and décolletage, in accordance with the assessment of indications.

  • Examination and blood draw, about 10 minutes: a small amount of blood is taken, as for a test.
  • Plasma separation, about 10 minutes: The test tube goes into the centrifuge. Meanwhile, anesthetic cream is applied to the skin.
  • Application, 15 to 20 minutes: plasma is introduced into the skin of the face, and by agreement also the neck or décolletage, using fine needles.
  • Total: 30 to 40 minutes.

PRP facial treatment is applied for conditions associated with the reduced regenerative capacity of the skin. The most common indications include fine lines and early signs of ageing, loss of tone, uneven texture and a tired appearance of the skin.

The therapy is particularly useful for thin and dehydrated skin that requires collagen stimulation and improved elasticity. It is also used for atrophic acne scars, where PRP can contribute to improving tissue quality, especially when combined with other regenerative methods.

It is important to emphasise that PRP treatment does not provide an immediate change, but rather works through the gradual activation of natural renewal processes, in accordance with the biological potential of the skin.

  • Face: quality, tone and texture of the skin.
  • Neck and décolletage: thin skin with fine wrinkles.
  • Hands: dry and thin skin.
  • Under the eyes: fine lines and thin skin. PRP does not remove dark circles caused by pigment or hollows. Read more on the page removal of dark circles under the eyes.
  • Acne scars: most commonly in combination with microneedling (Dermapen or SkinPen). Read more on the page acne scars.

The number of PRP treatments is determined individually, depending on the initial condition of the skin and the goal of the therapy. In practice, a series of three treatments at intervals of approximately four weeks is most commonly recommended in order to achieve a stable stimulation of regenerative processes.

Following the completion of the initial series, maintenance therapy is carried out at intervals deemed optimal by the physician, most commonly once to twice a year, in accordance with the condition of the skin and the expected results.

  • The first few days: Redness and any bruising subside, and the skin may appear fresher.
  • After a month: Before the second treatment, the skin is usually more even and smoother.
  • About three months after the series: The overall effect on texture, complexion and fine lines is estimated.

The change is gradual and moderate. In a review of studies, the most evidence exists for the improvement of skin texture.

It is important to emphasise that PRP treatment does not affect skin issues associated with pronounced volume loss, deep static wrinkles, hyperpigmentation changes or dark circles under the eyes of vascular or genetic origin. This therapy does not replace hyaluronic acid fillers, laser procedures or other specific aesthetic treatments that are intended to address the aforementioned conditions.

Before treatment:

  • One week before: Tell your doctor which medicines and supplements you are taking, especially those that affect blood clotting or act against pain and inflammation. Do not stop your treatment without consulting your doctor.
  • Two to three days before: Do not drink alcohol and do not exfoliate.
  • On the day of the treatment: Have breakfast and drink enough water, as blood is being taken. Come without makeup if you can.

After treatment:

  • The first few hours: Do not wash your face.
  • The first 12 to 24 hours: no makeup.
  • First 2 days: excluding saunas, swimming pools, intense training and alcohol.
  • The first 5 to 7 days: without scrubs, acid-based products and retinoids, and with sun protection.

We recommend planning your injectable treatment at least two weeks before an important event. If a series of treatments is required, the plan should start earlier to allow enough time for the full effect to develop.

PRP, polynucleotides or skin boosters?

All three treatments are carried out for skin quality, but they differ in what is introduced into the skin.
PRP facial treatment Polynucleotides Skin boosters
What is injected plasma from your blood purified DNA fragments hyaluronic acid, with or without additives
How it works growth factors stimulate skin renewal stimulate skin cells to regenerate and produce collagen they bind water and hydrate the skin
Most commonly for textured, tired skin, acne scars thin, exhausted skin and the eye area dry and dehydrated skin
Initial plan 3 treatments, spaced about a month apart 3 to 4 treatments, 2 to 4 weeks apart It depends on the product
Blood draw Yes What What
A doctor assesses what suits your skin during an examination. Read more on the pages polynucleotides and skin boosters.

PRP treatment cost

The price of a PRP treatment depends on the region being treated, the number of sessions required and the individual treatment plan. For regenerative procedures, it is important that the number of treatments and the interval between them are defined after an examination, in accordance with the condition of the skin and the therapeutic goal. Detailed information on prices is available on the page Price list, where all current treatments and therapy options are displayed. The final recommendation and plan are made by a doctor following a professional assessment.

Have you got a question?

Answers to frequently asked questions

The entire treatment lasts between 30 and 40 minutes, after which you return to your everyday activities.

PRP is not tied to a specific age. Its effect depends on the biological condition of the skin, not just age.

In younger people (20–30 years old), PRP is most commonly used preventatively, to preserve skin quality and for early acne scars. At this age, the regenerative potential is high, so the response to therapy is usually good.

Between the ages of 30 and 50, PRP is most commonly used for tone, elasticity and fine lines.

In individuals older than 55–60 years, the effect still exists, but the regenerative capacity is naturally lower. PRP can then improve skin quality, but it does not replace procedures for pronounced excess skin or deep wrinkles, so it is more often used as a supplement to other treatments.

An examination and individual assessment are mandatory before deciding on therapy. PRP is also used for hair loss, which we write more about on the page PRP hair treatment.

PRP is used to improve skin texture and complexion freshness. Changes develop gradually; an initial series of three treatments is usually planned, depending on the skin condition.

PRP is prepared from your blood, so allergic reactions are very rare. The most common are redness, swelling and minor bruises at the injection sites, which subside within 24 to 72 hours, and in some people up to a week. Serious complications are rare. That is why the treatment is performed by a doctor, under sterile conditions.

PRP treatment is not carried out in individuals with active malignancies, haematological disorders, severe forms of anaemia or coagulation disorders. It is also contraindicated in acute infections, inflammatory skin changes in the treatment region, as well as in uncontrolled systemic diseases. The therapy is not recommended during pregnancy or breastfeeding, nor in individuals using certain medications that affect blood clotting, except following prior medical assessment. In cases of autoimmune diseases and chronic conditions, the decision to perform the treatment is made individually, following a detailed medical history and risk assessment. Before every PRP treatment, it is essential to carry out an examination and take a complete medical history in order to rule out contraindications and assess whether the treatment is safe for you.

Book a facial PRP treatment in Belgrade

The Imedic Polyclinic is located at Kneza Miloša 23 street, 2nd floor, Belgrade. Opening hours: Monday–Sunday, 9:00–21:00.

Appointments are made by phone: 064 237 0707. If you contact us from abroad, we are also available via Viber and WhatsApp on the same number.

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Author: Dr Ivica Jeremić

Author: Dr Ivica Jeremić

Doctor of Medical Sciences (Molecular Medicine and Immunology), subspecialist in rheumatology, dermatology resident.

Updated:

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